Mild Redox-Neutral Formylation of Aryl Chlorides through the Photocatalytic Generation of Chlorine Radicals
Published in Angewandte Chemie International Edition, 2017
Recommended citation: Nielsen, Matthew K.^; Shields, Benjamin J.^; Liu, Junyi; Williams, M. J.; Zacuto, M. J.; Doyle, Abigail G. “Mild Redox-Neutral Formylation of Aryl Chlorides through the Photocatalytic Generation of Chlorine Radicals” Angew. Chem. Int. Ed. 2017, 56 7191–7194. ^Equal contributions. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201702079
We report a redox‐neutral formylation of aryl chlorides that proceeds through selective 2‐functionalization of 1,3‐dioxolane through nickel and photoredox catalysis. This scalable benchtop approach provides a distinct advantage over traditional reductive carbonylation in that no carbon monoxide, pressurized gas, or stoichiometric reductant is employed. The mild conditions give unprecedented scope from abundant and complex aryl chloride starting materials.